Tag Archives: PCR

Safe Yellow fever vaccine?

A friend informed me that they had to have a yellow fever certificate to travel. They are compelled (mandated) to receive the vaccine if they wish to get their travel visa, so I decided to look at adverse reactions.
Worst case scenario: Risk getting Yellow Fever-induced haemorrhagic fever or vaccine-induced “Yellow Fever Vaccine-Associated Viscerotropic Disease (YEL-AVD)”.

Yellow Fever factsheet
Signs and symptoms
YF varies in severity. The infection has an incubation period (time from infected mosquito feeding and symptoms developing) of three to six days. Initial symptoms include myalgia (muscle pain), pyrexia (high temperature), headache, anorexia (lack of appetite), nausea, and vomiting. In many patients there will be improvement in symptoms and gradual recovery three to four days after the onset of symptoms.

Within 24 hours of an apparent recovery, 15 to 25 percent of patients progress to a more serious illness. This takes the form of an acute haemorrhagic fever, in which there may be bleeding from the mouth, eyes, ears, and stomach, pronounced jaundice (yellowing of the skin, from which the disease gets its name), and renal (kidney) damage. The patient develops shock and there is deterioration of major organ function; 20 to 50 percent of patients who develop this form of the disease do not survive [18]. Infection results in lifelong immunity in those who recover.

“Reactions to YF vaccine are usually mild and short lived. They include myalgia (muscle pain), headache, and low-grade fever, typically occurring during the first five to ten days post vaccination, and will affect 10-30% of recipients.

Serious adverse events are rare and fall into three main categories: hypersensitivity reactions, vaccine-associated neurologic disease (YEL-AND) and vaccine-associated viscerotropic disease (YEL-AVD).

Hypersensitivity reactions
“The vaccine is propagated in chick embryos. The SPC for Stamaril® (the only YF vaccine used in the UK) lists sorbitol and lactose as excipients. Anaphylaxis (serious allergic reaction), because of sensitivity to either egg or other vaccine components, is estimated to occur at an incidence of 1.3 cases/100,000 doses distributed (US data) [21].”

Yellow Fever Vaccine-Associated Neurologic Disease (YEL-AND)
Post-vaccine encephalitis – encephalitis is an uncommon but serious condition in which the brain becomes inflamed (swollen) -has been recognised as a rare event since the early use of the vaccine. Cases were reported in very young infants during the 1950s (when there was no age restriction for vaccine administration). In the 1960s, when vaccine use was restricted to babies aged over six months, reduced numbers of post vaccine encephalitis were reported [6].”

Yellow Fever Vaccine-Associated Viscerotropic Disease (YEL-AVD)
“YF vaccine-associated viscerotropic disease (YEL-AVD) is a syndrome of fever and multi-organ failure that resembles severe YF disease;

One to eighteen days (median four days) following vaccination [12], patients with YEL-AVD develop fever, malaise, headache, and myalgia that progress to hepatitis (inflammation of the liver), hypotension (low blood pressure), and multi-organ failure. Death has occurred in more than 60 percent of reported cases worldwide [6]”

So to sum up,  15% to 25% non-vaccinated people -depending on their general health/vitality/life style – will develop the more serious version of Yellow Fever, which looks very much like like the vaccine-induced Yellow Fever Vaccine-Associated Viscerotropic Disease (YEL-AVD)! Also note that serious Yellow Fever infection leads to haemorrhagic fever.
Haemorrhagic Fever? Similar family to Ebola, Marburg and Lassa fever. It then begs the question on false positives. Would I get a positive response for Ebola (re:Congo) if I had Yellow Fever? The PCR test as the basis for commercial testing is flawed as pointed out by Jon Rappaport: The gold standard of medical tests is fake

Pro-vaxxers, troll farms comment away. All views are welcome. Honest bloggers are open to debate, discussions unlike multi billion dollar pharma cartels.

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Smartphone Device Detects HIV, Syphilis

http://www.webmd.com/hiv-aids/news/20150204/smartphone-device-detects-hiv-syphilis

The low-cost device can spot markers of the infectious diseases from a finger prick of blood in 15 minutes. It’s the first smartphone accessory that replicates all the functions of a laboratory-based blood test, according to the researchers.

“This is a new technology that uses smartphones to detect antibodies against HIV and syphilis. Although an encouraging development, there are significant limitations, such as comparison with confirmatory tests in standardized laboratories,” said Dr. Ambreen Khalil, an infectious disease specialist at Staten Island University Hospital, in Staten Island, N.Y.

The device — called a dongle — is small and light enough to fit into a hand, uses little power and will cost about $34 to make, according to the researchers.

Full Webmd Article

CDC – Laboratory diagnosis of Ebola virus disease

http://www.cdc.gov/vhf/ebola/diagnosis/
Ebola virus is detected in blood only after onset of symptoms, most notably fever, which accompany the rise in circulating virus within the patient’s body. It may take up to three days after symptoms start for the virus to reach detectable levels. Laboratory tests used in diagnosis include:

Timeline of Infection Diagnostic tests available
Within a few days after symptoms begin
  • Antigen-capture enzyme-linked immunosorbent assay (ELISA) testing
  • IgM ELISA
  • Polymerase chain reaction (PCR)
  • Virus isolation
Later in disease course or after recovery
  • IgM and IgG antibodies
Retrospectively in deceased patients
  • Immunohistochemistry testing
  • PCR
  • Virus isolation

Christopher H. Logue Virology Training Lead / Adjunct Professor of Virology

https://uk.linkedin.com/in/christopherlogue
Virology Training Lead – Novel and Dangerous Pathogens Training Group
Public Health England, Novel and Dangerous Pathogens Training
January 2013 – Present (1 year 11 months)PHE – Porton Down

Note: Novel and emerging would seem to be euphemisms for NEW!