Vaccination with the Live Attenuated Francisella novicida Mutant FTN0109 Protects against Pulmonary Tularemia

Holy smoke…forget Ebola! These crazies have a new candidate – Francisella Novicida mutand FTN0109.

“Francisella tularensis is considered a potential bioterrorism agent due to its low infectious dose, high mortality rate, and ability to be spread via the aerosol route.”

Scientific Research Publishing

Read  full  paper  at:

http://www.scirp.org/journal/PaperInformation.aspx?PaperID=53369#.VMBjJSzQrzE

ABSTRACT

Francisella tularensis is considered a potential bioterrorism agent due to its low infectious dose, high mortality rate, and ability to be spread via the aerosol route. We characterized the F. tularensis subspecies novicida mutant strain FTN0109 as a potential vaccine candidate against tularemia. This strain, which lacks an outer membrane lipoprotein, is attenuated in vitro and in vivo, as it exhibits reduced replication…

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